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Corticosteroids for dengue - why don't they work?

Abstract:

BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cyto...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0002592

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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
7
Issue:
12
Pages:
e2592
Publication date:
2013-12-12
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:444248
URN:
uri:7460fe29-9013-47dc-a582-bcd5a4fa98f8
UUID:
uuid:7460fe29-9013-47dc-a582-bcd5a4fa98f8
Local pid:
pubs:444248
Paper number:
12

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