- Abstract:
-
Ba2+ currents through L-type Ca2+ channels were recorded from cell-attached patches on mouse pancreatic beta cells. In 10 mM Ba2+, single-channel currents were recorded at -70 mV, the beta cell resting membrane potential. This suggests that Ca2+ influx at negative membrane potentials may contribute to the resting intracellular Ca2+ concentration and thus to basal insulin release. Increasing external Ba2+ increased the single-channel current amplitude and shifted the current-voltage relation t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1085/jgp.101.5.767
-
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- Journal:
- The Journal of general physiology
- Volume:
- 101
- Issue:
- 5
- Pages:
- 767-797
- Publication date:
- 1993-05-05
- DOI:
- EISSN:
-
1540-7748
- ISSN:
-
0022-1295
- URN:
-
uuid:7458cc3a-3b0a-48f2-b02a-c4c526bf1587
- Source identifiers:
-
115109
- Local pid:
- pubs:115109
- Language:
- English
- Keywords:
- Copyright date:
- 1993
Journal article
Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells.
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