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Journal article

Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells.

Abstract:

Ba2+ currents through L-type Ca2+ channels were recorded from cell-attached patches on mouse pancreatic beta cells. In 10 mM Ba2+, single-channel currents were recorded at -70 mV, the beta cell resting membrane potential. This suggests that Ca2+ influx at negative membrane potentials may contribute to the resting intracellular Ca2+ concentration and thus to basal insulin release. Increasing external Ba2+ increased the single-channel current amplitude and shifted the current-voltage relation t...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.101.5.767

Authors


Journal:
The Journal of general physiology
Volume:
101
Issue:
5
Pages:
767-797
Publication date:
1993-05-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:7458cc3a-3b0a-48f2-b02a-c4c526bf1587
Source identifiers:
115109
Local pid:
pubs:115109

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