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Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

Abstract:

Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication, repair, and cell cycle control. PCNA is a homotrimeric ring that, when encircling DNA, is not easily extractable. Consequently, the dynamics of protein-protein interactions established by PCNA at DNA replication sites is not well understood. We have used DNase I to release DNA-bound PCNA together with replication proteins including the p125-catalytic subunit of DNA polymerase delta (p125-pol delta), DNA liga...

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Publication status:
Published

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Publisher copy:
10.1016/j.yexcr.2003.10.025

Authors


Cazzalini, O More by this author
Stivala, LA More by this author
Scovassi, IA More by this author
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Journal:
Experimental cell research
Volume:
293
Issue:
2
Pages:
357-367
Publication date:
2004-02-05
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
URN:
uuid:7450232f-6516-434c-b929-bdb5fc791bad
Source identifiers:
100848
Local pid:
pubs:100848

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