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Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.

Abstract:

New therapeutic approaches in Alzheimer's disease are urgently needed. The normal plasma protein, serum amyloid P component (SAP), is always present in cerebrospinal fluid (CSF) and in the pathognomonic lesions of Alzheimer's disease, cerebrovascular and intracerebral Abeta amyloid plaques and neurofibrillary tangles, as a result of its binding to amyloid fibrils and to paired helical filaments, respectively. SAP itself may also be directly neurocytotoxic. Here, in this unique study in Alzhei...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0902640106

Authors


Kolstoe, SE More by this author
Bellotti, V More by this author
Robinson, CV More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
18
Pages:
7619-7623
Publication date:
2009-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:744c3773-5364-4959-82e4-84c63da26aa5
Source identifiers:
59404
Local pid:
pubs:59404

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