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Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.

Abstract:

Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) are being rendered increasingly ineffective, resulting in increasing morbidity, mortality, and economic and social costs. One strategy advocated for delaying the development of resistance to the remaining armory of effective drugs is the wide-scale deployment of artemisinin-based combination therapy. H...

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Publication status:
Published

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Authors


Pongtavornpinyo, W More by this author
Hastings, IM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
The American journal of tropical medicine and hygiene
Volume:
71
Issue:
2 Suppl
Pages:
179-186
Publication date:
2004-08-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:7447c6bb-f1da-498a-9de2-f7d7b6c6f2c7
Source identifiers:
32826
Local pid:
pubs:32826

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