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TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.

Abstract:

The T-cell receptor zeta (TCRzeta) chain is a master sensor and regulator of lymphocyte responses. Loss of TCRzeta expression has been documented in infectious, inflammatory, and malignant diseases, suggesting that it may serve to limit T-cell reactivity and effector responses at sites of tissue damage. These observations prompted us to explore the relationship between TCRzeta expression and effector function in T cells. We report here that TCRzeta(dim) lymphocytes are enriched for antigen-ex...

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Publication status:
Published

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Authors


Gorman, CL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
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Journal:
Blood
Volume:
109
Issue:
10
Pages:
4328-4335
Publication date:
2007-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:7445a223-aa57-4414-a271-eac7f8bb587c
Source identifiers:
224207
Local pid:
pubs:224207

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