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Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection

Abstract:

Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excluding relationship with the pathogen Neisseria meningitidis. Here we report controlled human infection with genomically-defined N. lactamica and subsequent bacterial microevolution during 26 weeks of colonisation. We find that most mutations that occur during nasopharyngeal carriage are transient indels within repetitive tracts of putative phase-variable loci associated with host-microbe intera...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07235-5

Authors


Cleary, DW More by this author
Gorringe, A More by this author
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Grant:
Sir Christopher Benson Studentship
Wessex Institute of Virology and Infectious Disease More from this funder
Southampton NIHR Biomedical Research Centre More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
4753
Publication date:
2018-11-12
Acceptance date:
2018-10-17
DOI:
EISSN:
2041-1723
Pubs id:
pubs:932034
URN:
uri:7444f813-4941-4e4e-b646-5104753762e7
UUID:
uuid:7444f813-4941-4e4e-b646-5104753762e7
Local pid:
pubs:932034

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