Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excluding relationship with the pathogen Neisseria meningitidis. Here we report controlled human infection with genomically-defined N. lactamica and subsequent bacterial microevolution during 26 weeks of colonisation. We find that most mutations that occur during nasopharyngeal carriage are transient indels within repetitive tracts of putative phase-variable loci associated with host-microbe intera...Expand abstract
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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.
Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection
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