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From Parkinsonian thalamic activity to restoring thalamic relay using deep brain stimulation: new insights from computational modeling.

Abstract:

We present a computational model of a thalamocortical relay neuron for exploring basal ganglia thalamocortical loop behavior in relation to Parkinson's disease and deep brain stimulation (DBS). Previous microelectrode, single-unit recording studies demonstrated that oscillatory interaction within and between basal ganglia nuclei is very often accompanied by synchronization at Parkinsonian rest tremor frequencies (3-10 Hz). These oscillations have a profound influence on thalamic projections a...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Journal of neural engineering
Volume:
8
Issue:
6
Pages:
066005
Publication date:
2011-12-01
DOI:
EISSN:
1741-2552
ISSN:
1741-2560
Source identifiers:
266850
Language:
English
Keywords:
Pubs id:
pubs:266850
UUID:
uuid:7432c44e-de74-4077-a160-f8f793543336
Local pid:
pubs:266850
Deposit date:
2014-06-24

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