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From Parkinsonian thalamic activity to restoring thalamic relay using deep brain stimulation: new insights from computational modeling.

Abstract:

We present a computational model of a thalamocortical relay neuron for exploring basal ganglia thalamocortical loop behavior in relation to Parkinson's disease and deep brain stimulation (DBS). Previous microelectrode, single-unit recording studies demonstrated that oscillatory interaction within and between basal ganglia nuclei is very often accompanied by synchronization at Parkinsonian rest tremor frequencies (3-10 Hz). These oscillations have a profound influence on thalamic projections a...

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Authors


Meijer, HG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Lourens, MA More by this author
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Journal:
Journal of neural engineering
Volume:
8
Issue:
6
Pages:
066005
Publication date:
2011-12-05
DOI:
EISSN:
1741-2552
ISSN:
1741-2560
URN:
uuid:7432c44e-de74-4077-a160-f8f793543336
Source identifiers:
266850
Local pid:
pubs:266850

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