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A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

Abstract:

Many bacteria use a type III secretion system to inject effector proteins into host cells. Selection and export of the effectors is controlled by a set of soluble proteins at the cytosolic interface of the membrane spanning type III secretion “injectisome”. Combining fluorescence microscopy, biochemical interaction studies and fluorescence correlation spectroscopy, we show that in live Yersinia enterocolitica bacteria these soluble proteins form complexes both at the injectisome and in t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15940

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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Author
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
Article: 15940
Publication date:
2017-06-27
Acceptance date:
2017-05-15
DOI:
ISSN:
2041-1723
Pubs id:
pubs:695960
URN:
uri:74290d0a-7049-4831-816d-1d8ead6b91b7
UUID:
uuid:74290d0a-7049-4831-816d-1d8ead6b91b7
Local pid:
pubs:695960

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