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Regulation of hypoxia-induced cell death in human tenocytes.

Abstract:

Degenerate shoulder tendons display evidence of hypoxia. However tendons are relatively avascular and not considered to have high oxygen requirements and the vulnerability of tendon cells to hypoxia is unclear. Cultured human tenocytes were exposed to hypoxia and the cellular response detected using QPCR, Western blotting, viability, and ELISA assays. We find that tenocytes respond to hypoxia in vitro by activating classical HIF-1α-driven pathways. Total hypoxia caused significant tenocyte ap...

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Publisher copy:
10.1155/2012/984950

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Advances in orthopedics
Volume:
2012
Pages:
984950
Publication date:
2012-01-01
DOI:
EISSN:
2090-3472
ISSN:
2090-3464
URN:
uuid:741bc3d9-cf99-4b7b-8289-66707824e339
Source identifiers:
374243
Local pid:
pubs:374243
Language:
English

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