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Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

Abstract:

BACKGROUND: There is evidence that iron may play a role in the pathology of Alzheimer's disease (AD). There may be genetic factors that contribute to iron deposition resulting in tissue damage thus exacerbating AD. METHODS: We have genotyped 269 healthy elderly controls, 191 cases with definite or probable AD, and 69 with mild cognitive impairment (MCI) from the OPTIMA cohort. RESULTS: We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of...

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Publication status:
Published

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Publisher copy:
10.1136/jmg.2003.015552

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Journal:
Journal of medical genetics
Volume:
41
Issue:
4
Pages:
261-265
Publication date:
2004-04-01
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
Source identifiers:
195483

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