Journal article icon

Journal article

Influence of farnesyl transferase inhibitor treatment on epidermal growth factor receptor status.

Abstract:

The radiolabelled growth factor [(123/125)I] I-hEGF is evaluated in vitro and in vivo to monitor the acute effects on the EGFR of R115777, a farnesyl transferase inhibitor (FTI). Upregulation of the EGFR after incubation with R115777 correlated linearly with FTI induced acute growth inhibition. Receptor mediated [125I] I-hEGF internalization decreased following R115777 treatment. Preliminary data suggest that the net in vivo effect is a decrease of [123I] I-hEGF uptake in the tumour. These fi...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Thonissen, T More by this author
Kersemans, V More by this author
Van De Wiele, C More by this author
Lahorte, C More by this author
Expand authors...
Journal:
Nuclear medicine and biology
Volume:
31
Issue:
6
Pages:
679-689
Publication date:
2004-08-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:7418776e-6f74-4b24-bfe8-c53bae4ba8cd
Source identifiers:
257022
Local pid:
pubs:257022

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP