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A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes

Abstract:

In trypanosomes, the large mitochondrial genome within the kinetoplast is physically connected to the flagellar basal bodies and is segregated by them during cell growth. The structural linkage enabling these phenomena is unknown. We have developed novel extraction/fixation protocols to characterize the links involved in kinetoplast-flagellum attachment and segregation. We show that three specific components comprise a structure that we have termed the tripartite attachment complex (TAC). The...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1091/mbc.E02-08-0525

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Institution:
University of Manchester
Department:
School of Biological Sciences
More by this author
Institution:
University of Manchester
Department:
School of Biological Sciences
More by this author
Institution:
University of Manchester
Department:
School of Biological Sciences
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Funding agency for:
Derrick R. Robinson
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Funding agency for:
Keith Gull
United Nations Developmental Program/ World Bank/ World Health Organization More from this funder
Wellcome Trust More from this funder
Publisher:
The American Society for Cell Biology Publisher's website
Journal:
Molecular Biology of the Cell Journal website
Volume:
14
Issue:
5
Pages:
1769-1779
Publication date:
2003-05-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:74136472-0c37-4670-9457-558a93ff3c63
Local pid:
ora:1513

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