Journal article icon

Journal article

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.

Abstract:
Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP. © 2010 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/anie.200901694

Authors


Saraogi, I More by this author
Becerril, J More by this author
Estroff, LA More by this author
Miranker, AD More by this author
Expand authors...
Journal:
Angewandte Chemie (International ed. in English)
Volume:
49
Issue:
4
Pages:
736-739
Publication date:
2010
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:74108b49-c5d5-456b-99ff-f92d55888e3c
Source identifiers:
117487
Local pid:
pubs:117487

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP