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Journal article

The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.

Abstract:

The three isoforms of antigen 85 (A, B, and C) are the most abundant secreted mycobacterial proteins and catalyze transesterification reactions that synthesize mycolated arabinogalactan, trehalose monomycolate (TMM), and trehalose dimycolate (TDM), important constituents of the outermost layer of the cellular envelope of Mycobacterium tuberculosis. These three enzymes are nearly identical at the active site and have therefore been postulated to exist to evade host immunity. Distal to the acti...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m114.581579

Authors


Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
Journal of biological chemistry
Volume:
289
Issue:
36
Pages:
25041-25053
Publication date:
2014-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
476251
Language:
English
Keywords:
Pubs id:
pubs:476251
UUID:
uuid:73eb8d25-3346-4eba-b4ba-dfbae5aeb50a
Local pid:
pubs:476251
Deposit date:
2014-07-22

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