Journal article
Cell cycle-coupled expansion of AR activity promotes cancer progression.
- Abstract:
-
The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. While initially effective, recurrent tumors ultimately arise for which there is no durable cure. Despite the dependence of PCa on AR activity throughout the course of disease, delineation of the AR-dependent transcriptional network that governs disease progression remains elusive, and the function of AR i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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- Files:
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(pdf, 1.9MB)
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- Publisher copy:
- 10.1038/onc.2016.334
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Authors
Funding
Pennsylvania Department of Health
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Oncogene Journal website
- Volume:
- 36
- Issue:
- 12
- Pages:
- 1655-1668
- Publication date:
- 2016-09-05
- Acceptance date:
- 2016-08-03
- DOI:
- EISSN:
-
1476-5594
- ISSN:
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0950-9232
- Pubs id:
-
pubs:817474
- URN:
-
uri:73eb34aa-e421-4190-ba38-dcd2437b77ac
- UUID:
-
uuid:73eb34aa-e421-4190-ba38-dcd2437b77ac
- Local pid:
- pubs:817474
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2016
- Notes:
- © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved
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