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Journal article

Cell cycle-coupled expansion of AR activity promotes cancer progression.

Abstract:

The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. While initially effective, recurrent tumors ultimately arise for which there is no durable cure. Despite the dependence of PCa on AR activity throughout the course of disease, delineation of the AR-dependent transcriptional network that governs disease progression remains elusive, and the function of AR i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/onc.2016.334

Authors


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ORCID:
0000-0003-2931-3652
Comstock, CES More by this author
Augello, MA More by this author
Goodwin, JF More by this author
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Pennsylvania Department of Health More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Oncogene Journal website
Volume:
36
Issue:
12
Pages:
1655-1668
Publication date:
2016-09-05
Acceptance date:
2016-08-03
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Pubs id:
pubs:817474
URN:
uri:73eb34aa-e421-4190-ba38-dcd2437b77ac
UUID:
uuid:73eb34aa-e421-4190-ba38-dcd2437b77ac
Local pid:
pubs:817474

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