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Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells.

Abstract:

AIMS/HYPOTHESIS: Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide blocks recombinant beta-cell KATP channels (Kir6.2/SUR1) but not heart (Kir6.2/SUR2A) or smooth muscle (Kir6.2/SUR2B) KATP channels with high potency. In this study, we examined...

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Publication status:
Published

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Publisher copy:
10.1007/s001250100595

Authors


Lawrence, CL More by this author
Rodrigo, GC More by this author
Hayabuchi, Y More by this author
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Journal:
Diabetologia
Volume:
44
Issue:
8
Pages:
1019-1025
Publication date:
2001-08-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:73e210c9-1cfa-437f-8d16-8185dd7ce688
Source identifiers:
114562
Local pid:
pubs:114562

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