- Abstract:
-
We have recently developed a new experimental vaccine vector system based on Autographa californica nucleopolyhedrosis virus (AcNPV) termed the "Baculovirus Dual Expression System", which drives expression of vaccine candidate antigens by a dual promoter that consists of tandemly arranged baculovirus-derived polyhedrin and mammalian-derived CMV promoters. The present study used this system to generate a Plasmodium vivax transmission-blocking immunogen (AcNPV-Dual-Pvs25). AcNPV-Dual-Pvs25 not ...
Expand abstract - Publisher copy:
- 10.1016/j.vaccine.2010.06.100
-
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- Journal:
- Vaccine
- Volume:
- 28
- Issue:
- 37
- Pages:
- 6014-6020
- Publication date:
- 2010-08-05
- DOI:
- EISSN:
-
1873-2518
- ISSN:
-
0264-410X
- URN:
-
uuid:73d9ef44-1082-4102-ba92-81713f95443d
- Source identifiers:
-
269058
- Local pid:
- pubs:269058
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission.
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