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Genetic factors of the disease course after sepsis: a genome-wide study for 28 day mortality

Abstract:

Sepsis is the dysregulated host response to an infection which leads to life-threatening organ dysfunction that varies by host genomic factors. We conducted a genome-wide association study (GWAS) in 740 adult septic patients and focused on 28day mortality as outcome. Variants with suggestive evidence for an association (p≤10(-5)) were validated in two additional GWA studies (n=3470) and gene coding regions related to the variants were assessed in an independent exome sequencing study (n=74). ...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2016.08.043

Authors


Scherag, A More by this author
Schöneweck, F More by this author
Kesselmeier, M More by this author
Taudien, S More by this author
Platzer, M More by this author
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
12
Issue:
October 2016
Pages:
239–246
Publication date:
2016-09-15
Acceptance date:
2016-08-27
DOI:
ISSN:
2352-3964
Pubs id:
pubs:646041
URN:
uri:73d54cc5-b034-40be-8173-59c1a30133a9
UUID:
uuid:73d54cc5-b034-40be-8173-59c1a30133a9
Local pid:
pubs:646041

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