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Journal article

Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study.

Abstract:

BACKGROUND AND AIMS: The aim was to determine the toxicity, clinical and immune responses to the murine monoclonal anti-carcinoembryonic antigen (CEA) antibody, PR1A3, in patients with advanced colorectal cancer. MATERIALS AND METHODS: Fifteen patients with advanced colorectal cancer received either 0.5-, 1.0- or 5.0-mg doses of PR1A3 mixed with 10% w/v Alum adjuvant (Superfos Biosector, Denmark) intradermally at 4-week intervals for 3 months. Patient serum was assessed for anti-idiotypic (A...

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Publication status:
Published

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Publisher copy:
10.1007/s00384-004-0726-x

Authors


Wilkinson, RW More by this author
Syrigos, KN More by this author
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Journal:
International journal of colorectal disease
Volume:
20
Issue:
5
Pages:
403-414
Publication date:
2005-09-05
DOI:
EISSN:
1432-1262
ISSN:
0179-1958
URN:
uuid:73d53d8c-0e15-4928-8f27-cd14369f8c2f
Source identifiers:
179997
Local pid:
pubs:179997

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