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Thesis

Application of magnetic resonance for non-invasive phenotyping of mice with altered metabolism

Abstract:

Changes in myocardial energetics have been implicated in the pathophysiology of heart failure (HF). However, the precise contribution of creatine (Cr) / phosphocreatine (PCr) / creatine kinase (CK) energy buffer and transfer remains unclear. The aim of this thesis was to study the effects on murine cardiac function of both impairment and enhancement of creatine metabolism.

In order to longitudinally follow the cause and effect relationship of myocardial creatine concentration, a non...

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Neubauer
Oxford college:
Christ Church
Department:
Medical Sciences Division - Cardiovascular Medicine
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Funding agency for:
Kiterie Maud Edwige Faller
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:73d1b728-b9e5-41fa-999f-30025b70d25e
Local pid:
ora:7709

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