Carbohydrate binding molecules in malaria pathology.

Journal article

Interactions between parasite-encoded proteins and host carbohydrate molecules are essential at multiple stages in the life cycle of the malaria-causing parasite, Plasmodium falciparum, and these interactions are targets for the development of therapeutics to treat the disease. Here we review recent structural studies of carbohydrate binding modules that mediate recognition events important for cell invasion and cytoadhesion. In particular we focus on the structures of two molecules; the eryt...

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Authors: Brown, A; Higgins, M

• Publication status: Published
• Journal: Current opinion in structural biology
• Volume: 20
• Issue: 5
• Pages: 560-566
• Publication date: 2010-10-01
• DOI: 10.1016/j.sbi.2010.06.008
• EISSN: 1879-033X
• ISSN: 0959-440X
• Language: English
• Keywords: Erythrocytes; N-Acetylneuraminic Acid; Cell Adhesion; Plasmodium falciparum; Malaria; Carbohydrate Metabolism; Animals; Humans