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Journal article

Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium

Abstract:

ADP-ribosyltransferases (ARTs) promote repair of DNA single strand breaks (SSBs) and disruption of this pathway by Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) is toxic to cells with defects in homologous recombination (HR). Here we show that this relationship is conserved in the simple eukaryote Dictyostelium and exploit this organism to define mechanisms that drive resistance of HR-deficient cells to PARPi. Dictyostelium cells disrupted in exonuclease I

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkx639

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Department:
St Peters College
Role:
Author
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Grant:
NC/K00137X/1
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
17
Pages:
10056-10067
Publication date:
2017-07-24
Acceptance date:
2017-07-11
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:708189
URN:
uri:73c3130e-d611-42af-be7c-b933835cbb6a
UUID:
uuid:73c3130e-d611-42af-be7c-b933835cbb6a
Local pid:
pubs:708189

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