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Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.

Abstract:

BACKGROUND: The syndrome of progressive encephalopathy with limb rigidity has been historically termed progressive encephalomyelitis with rigidity and myoclonus (PERM) or stiff-person syndrome plus. METHODS: The case is presented of a previously healthy 28-year-old man with a rapidly fatal form of PERM developing over 2 months. RESULTS: Serum antibodies to both NMDA receptors (NMDAR) and glycine receptors (GlyR) were detected postmortem, and examination of the brain confirmed an autoimmune e...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Neurology
Volume:
77
Issue:
5
Pages:
439-443
Publication date:
2011-08-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:73b11b7f-f640-4eab-9f44-536c5000478b
Source identifiers:
241889
Local pid:
pubs:241889

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