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THE DISPOSITION AND METABOLISM OF SULPHASALAZINE (SALICYLAZOSULFAPYRIDINE) IN MAN

Abstract:

We have investigated the disposition and metabolism of sulfasalazine (SASP) in eight adults with and without inflammatory bowel disease. SASP is poorly absorbed (< 12%) and the half-time measured in the serum, 10.2 h, is probably the half-time of absorption and therefore an overestimate of the true half-time. The apparent volume of distribution is low (< 9 l). Renal and biliary clearance rates are low (5.5 and 2.1 ml min -1 respectively) probably due to a high de...

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Publication status:
Published

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Journal:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume:
13
Issue:
4
Pages:
523-528
Publication date:
1982-01-01
ISSN:
0306-5251
URN:
uuid:739b5cc3-9982-439e-895d-fdb54c5e6bb6
Source identifiers:
322103
Local pid:
pubs:322103
Language:
English

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