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Thesis

Interplay between chromatin conformation and transcription in eukaryotes

Abstract:

The three-dimensional organization of the genome is important for various processes such as transcription, replication, and repair. Several studies have shown that the genome is organized into long-range and short-range chromatin loops. Gene loops represent a short-range chromatin loop, synonymous with the juxtaposition of promoter and terminator regions of a gene. In Chapter III, I investigate the mechanism of gene-loop formation in a constitutively expressed gene, mouse serum albumin (

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Institution:
University of Oxford
Research group:
Prof. Nicholas J Proudfoot
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathology

Contributors

Role:
Supervisor
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Funding agency for:
Shweta Bhardwaj
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:7395c490-a296-48e8-b8ca-afd785d516b0
Local pid:
ora:11562
Language:
English
Keywords:
Subjects:

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