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Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion.

Abstract:

We administered ghrelin, a novel growth hormone-releasing hormone, to isolated perfused rat hearts, coronary arterioles, and cultured neonatal cardiomyocytes to determine its effects on coronary vascular tone, contractility, and natriuretic peptide secretion and gene expression. We also determined cardiac levels of ghrelin and whether the heart is a source of the circulating peptide. Ghrelin dose dependently increased coronary perfusion pressure (44 +/- 9%, P < 0.01), constricted isolated ...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00193.2004

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
287
Issue:
4
Pages:
H1522-H1529
Publication date:
2004-10-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:737d81ec-7f8c-4f02-98ba-8d910391cfdf
Source identifiers:
164474
Local pid:
pubs:164474

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