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Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.

Abstract:

In this study, we show that extracts and a purified compound of Warburgia salutaris exhibit anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG Pasteur. The extracts did not inhibit growth of Escherichia coli and were not toxic to cultured mammalian macrophage cells at the concentrations at which anti-mycobacterial activity was observed. The extract and pure compound inhibited pure recombinant arylamine N-acetyltransferase (NAT), an enzyme involved...

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Publisher copy:
10.1016/j.bmc.2007.02.011

Authors


Madikane, VE More by this author
Russell, AJ More by this author
Campbell, WE More by this author
Claridge, TD More by this author
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Journal:
Bioorganic and medicinal chemistry
Volume:
15
Issue:
10
Pages:
3579-3586
Publication date:
2007-05-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:7376b6fc-c47e-4e10-8ca3-1202f8226609
Source identifiers:
33789
Local pid:
pubs:33789

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