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Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.

Abstract:

Human Hep27 was originally isolated from growth-arrested HepG2 cells and identified as a member of the superfamily of short-chain dehydrogenases/reductases (SDR). Its substrate specificity has not been determined, but a cross-species comparison suggests that it occurs in widely divergent species, such as human, Cenorhabditis elegans, Drosophila and Arabidopsis thaliana. In this study, Hep27 was expressed as a His(6) fusion protein, and subjected to a substrate screen, using a compound library...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-006-6013-y

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Journal:
Cellular and molecular life sciences : CMLS
Volume:
63
Issue:
10
Pages:
1205-1213
Publication date:
2006-05-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:737452b6-57be-4132-8a52-b09753bc519b
Source identifiers:
108871
Local pid:
pubs:108871

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