- Abstract:
-
Human Hep27 was originally isolated from growth-arrested HepG2 cells and identified as a member of the superfamily of short-chain dehydrogenases/reductases (SDR). Its substrate specificity has not been determined, but a cross-species comparison suggests that it occurs in widely divergent species, such as human, Cenorhabditis elegans, Drosophila and Arabidopsis thaliana. In this study, Hep27 was expressed as a His(6) fusion protein, and subjected to a substrate screen, using a compound library...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00018-006-6013-y
-
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- Journal:
- Cellular and molecular life sciences : CMLS
- Volume:
- 63
- Issue:
- 10
- Pages:
- 1205-1213
- Publication date:
- 2006-05-05
- DOI:
- EISSN:
-
1420-9071
- ISSN:
-
1420-682X
- URN:
-
uuid:737452b6-57be-4132-8a52-b09753bc519b
- Source identifiers:
-
108871
- Local pid:
- pubs:108871
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.
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