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Structural plasticity of the Semliki Forest virus glycome upon interspecies transmission.

Abstract:

Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-translational processing of viral envelope glycoproteins. Alphavirus biogenesis has been extensively studied, and the Semliki Forest virus E1 and E2 glycoproteins have been shown to exhibit differing degrees of processing of N-linked glycans. However the composition of these glycans, including that arising from different host cells, has not been determined. Here we determined the chemical compositio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/pr401162k

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Huiskonen, JT
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Funding agency for:
Bowden, TA
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Proteome Research Journal website
Volume:
13
Issue:
3
Pages:
1702-1712
Publication date:
2014-01-28
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:73710274-a7d3-4ce4-8f03-0526a745ae16
Source identifiers:
447581
Local pid:
pubs:447581

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