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Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex.

Abstract:

OBJECTIVES: Results from recent drug trials suggest a role for the cholinergic system in the manifestation of neuropsychiatric symptoms in AD. To date, the status of muscarinic acetylcholine receptor subtypes in AD in relation to accompanying behavioral disturbances is unknown. This study aimed to measure alterations of muscarinic M(1) and M(2) receptor binding in the frontal and temporal cortex of AD and to correlate the neurochemical findings with clinical features. METHODS: The cognitive a...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.57.5.805

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Neurology
Volume:
57
Issue:
5
Pages:
805-811
Publication date:
2001-09-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:7363a688-782e-4d48-9940-70bca8bc3f6f
Source identifiers:
242408
Local pid:
pubs:242408

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