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Quantification of hepatic FOXP3+ T-lymphocytes in HIV/hepatitis C coinfection

Abstract:

Coinfection with HIV adversely impacts every stage of hepatitis C (HCV) infection. Liver damage in HCV infection results from host antiviral responses rather than direct viral pathogenesis. Despite depressed cellular immunity, coinfected patients show accelerated hepatic fibrosis compared with HCV monoinfected patients. This paradox is poorly understood. T-regulatory (Treg) cells (CD4+ and FOXP3+) are hypothesized to limit hepatic damage in HCV. Our hypothesis was that reduced frequency of he...

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Publisher copy:
10.1111/jvh.12141

Authors


Williams, SK More by this author
Donaldson, E More by this author
Van Der Kleij, T More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
Journal of Viral Hepatitis
Volume:
21
Issue:
4
Pages:
251-259
Publication date:
2014
DOI:
EISSN:
1365-2893
ISSN:
1352-0504
URN:
uuid:73606092-9dc4-471c-99e5-89bfaf6a105d
Source identifiers:
474080
Local pid:
pubs:474080

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