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Pre-treatment proliferation and the outcome of conventional and accelerated radiotherapy.

Abstract:

This study investigated the influence of pre-treatment proliferation characteristics, assessed by Ki-67 staining, in patients treated in the CHART trial of accelerated radiotherapy in head and neck cancer. Histological material from 402 patients was collected and stained for the presence and pattern of Ki-67 staining. Locoregional control and overall survival were the main clinical endpoints. Increasing Ki-67 positivity was associated with decreasing differentiation (P < 0.001) and increas...

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Publisher copy:
10.1016/j.ejca.2005.10.022

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Journal:
European journal of cancer (Oxford, England : 1990)
Volume:
42
Issue:
3
Pages:
363-371
Publication date:
2006-02-05
DOI:
EISSN:
1879-0852
ISSN:
0959-8049
URN:
uuid:73425d71-5d04-41bc-abff-33173ee035c8
Source identifiers:
283422
Local pid:
pubs:283422

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