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A genome-wide association study of global gene expression.

Abstract:

We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virus-transformed lymphoblastoid cell lines. We found that 15,084 transcripts (28%) representing 6,660 genes had narrow-sense heritabilities (H2) > 0.3. We executed genome-wide associati...

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Publication status:
Published

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Publisher copy:
10.1038/ng2109

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Journal:
Nature genetics
Volume:
39
Issue:
10
Pages:
1202-1207
Publication date:
2007-10-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:733d99a9-210b-43fb-beb2-799d160857b9
Source identifiers:
66720
Local pid:
pubs:66720

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