Journal article icon

Journal article

In vitro base excision repair using mammalian cell extracts.

Abstract:

Base excision repair (BER) is an essential cellular mechanism that maintains genome stability by repairing DNA damage, such as DNA base lesions, base loss (AP sites) and single strand breaks, generated through endogenous metabolism or via exogenous mutagens. Therefore, in vitro BER assays are important for our understanding of the mechanism of cellular response to mutagens and may also reveal important information about the development of several DNA repair-related human diseases, such as can...

Expand abstract

Actions


Access Document


Authors


Parsons, JL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
920
Pages:
245-262
Publication date:
2012
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:733928ba-d190-4fa4-8580-1411cea99924
Source identifiers:
350546
Local pid:
pubs:350546

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP