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Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: biomimetic glycosaminoglycan analogues.

Abstract:

The load-bearing biomechanical role of the intervertebral disc is governed by the composition and organization of its major macromolecular components, collagen and aggrecan. The major function of aggrecan is to maintain tissue hydration, and hence disc height, under the high loads imposed by muscle activity and body weight. Key to this role is the high negative fixed charge of its glycosaminoglycan side chains, which impart a high osmotic pressure to the tissue, thus regulating and maintainin...

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Publication status:
Published

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Authors


Roberts, S More by this author
Bramhill, J More by this author
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Journal:
Acta biomaterialia
Volume:
10
Issue:
3
Pages:
1124-1133
Publication date:
2014-03-05
DOI:
EISSN:
1878-7568
ISSN:
1742-7061
URN:
uuid:73387237-54c1-4a1c-8c99-b76c56754d64
Source identifiers:
440147
Local pid:
pubs:440147

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