Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes.

Journal article

Abnormalities of the anterior cingulate cortex have previously been described in schizophrenia, major depressive disorder and bipolar disorder. In this study 2-DE was performed followed by mass spectrometric sequencing to identify disease-specific protein changes within the anterior cingulate cortex in these psychiatric disorders. The 2-DE system comprised IPGs 4-7 and 6-9 in the first, IEF dimension and SDS-PAGE in the second dimension. Resultant protein spots were compared between control a...

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Authors: Beasley, C; Pennington, K; Behan, A; Wait, R; Dunn, M

• Publication status: Published
• Journal: Proteomics
• Volume: 6
• Issue: 11
• Pages: 3414-3425
• Publication date: 2006-06-01
• DOI: 10.1002/pmic.200500069
• EISSN: 1615-9861
• ISSN: 1615-9853
• Language: English
• Keywords: Bipolar Disorder; Humans; Proteome; Schizophrenia; Adult; Middle Aged; Depressive Disorder, Major; Female; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Electrophoresis, Gel, Two-Dimensional; Gyrus Cinguli; Male