Journal article
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.
- Abstract:
-
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder caused by mutations in the dystrophin gene that result in the absence of the membrane-stabilizing protein dystrophin. Dystrophin-deficient muscle fibres are fragile and susceptible to an influx of Ca(2+), which activates inflammatory and muscle degenerative pathways. At present there is no cure for DMD, and existing therapies are...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nature10980
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Authors
Bibliographic Details
- Journal:
- Nature
- Volume:
- 484
- Issue:
- 7394
- Pages:
- 394-398
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:73115a22-533a-48ec-8a52-0017949abca2
- Source identifiers:
-
325419
- Local pid:
- pubs:325419
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2012
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