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Journal article

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.

Abstract:

Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder caused by mutations in the dystrophin gene that result in the absence of the membrane-stabilizing protein dystrophin. Dystrophin-deficient muscle fibres are fragile and susceptible to an influx of Ca(2+), which activates inflammatory and muscle degenerative pathways. At present there is no cure for DMD, and existing therapies are...

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Publication status:
Published

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Publisher copy:
10.1038/nature10980

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Journal:
Nature
Volume:
484
Issue:
7394
Pages:
394-398
Publication date:
2012-04-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:73115a22-533a-48ec-8a52-0017949abca2
Source identifiers:
325419
Local pid:
pubs:325419

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