Journal article
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.
- Abstract:
-
Centrosomes associate with spindle poles; thus, the presence of two centrosomes promotes bipolar spindle assembly in normal cells. Cancer cells often contain supernumerary centrosomes, and to avoid multipolar mitosis and cell death, these are clustered into two poles by the microtubule motor protein HSET. We report the discovery of an allosteric inhibitor of HSET, CW069, which we designed using a methodology on an interface of chemistry and biology. Using this approach, we explored millions o...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.chembiol.2013.09.012
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Authors
Bibliographic Details
- Journal:
- Chemistry and biology
- Volume:
- 20
- Issue:
- 11
- Pages:
- 1399-1410
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1879-1301
- ISSN:
-
1074-5521
- Source identifiers:
-
438889
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:438889
- UUID:
-
uuid:730ded60-d80a-4eca-9d53-2bd9f7f00713
- Local pid:
- pubs:438889
- Deposit date:
- 2013-12-12
Terms of use
- Copyright date:
- 2013
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