Journal article icon

Journal article

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.

Abstract:

Centrosomes associate with spindle poles; thus, the presence of two centrosomes promotes bipolar spindle assembly in normal cells. Cancer cells often contain supernumerary centrosomes, and to avoid multipolar mitosis and cell death, these are clustered into two poles by the microtubule motor protein HSET. We report the discovery of an allosteric inhibitor of HSET, CW069, which we designed using a methodology on an interface of chemistry and biology. Using this approach, we explored millions o...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Chemistry and biology
Volume:
20
Issue:
11
Pages:
1399-1410
Publication date:
2013-11-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Source identifiers:
438889

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP