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Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

Abstract:

Bacterial metallo-β-lactamases (MBLs) are involved in resistance to β-lactam antibiotics including cephalosporins. Human SNM1A and SNM1B are MBL superfamily exonucleases that play a key role in the repair of DNA interstrand cross-links, which are induced by antitumour chemotherapeutics, and are therefore targets for cancer chemosensitization. We report that cephalosporins are competitive inhibitors of SNM1A and SNM1B exonuclease activity; both the intact β-lactam and their hydrolysed products...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/C6CC00529B

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Publication date:
2016-04-18
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Local pid:
pubs:618058

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