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Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart.

Abstract:

In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss t...

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Publication status:
Published

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Publisher copy:
10.1098/rsta.2008.0311

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Journal:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Volume:
367
Issue:
1896
Pages:
2311-2331
Publication date:
2009-06-05
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
URN:
uuid:72e11fbb-b1a7-4c0b-90ce-3fd26aca4832
Source identifiers:
264825
Local pid:
pubs:264825
Language:
English
Keywords:

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