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Cytotoxic T lymphocytes form an antigen-independent ring junction.

Abstract:

Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cell receptor cluster, the central supramolecular activation cluster (cSMAC). In CD8(+) cytotoxic T lymphocytes, the immunological synapse is thought to facilitate specific killing by confining cytotoxic agents to the synaptic cleft. We have investigated the interaction of human CTLs and helper T cells w...

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Publisher copy:
10.1172/jci19337

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Journal:
Journal of clinical investigation
Volume:
113
Issue:
1
Pages:
49-57
Publication date:
2004-01-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
482636

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