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Inhibition of [FeFe]-hydrogenases by formaldehyde and wider mechanistic implications for biohydrogen activation.

Abstract:

Formaldehyde-a rapid and reversible inhibitor of hydrogen evolution by [FeFe]-hydrogenases-binds with a strong potential dependence that is almost complementary to that of CO. Whereas exogenous CO binds tightly to the oxidized state known as H(ox) but very weakly to a state two electrons more reduced, formaldehyde interacts most strongly with the latter. Formaldehyde thus intercepts increasingly reduced states of the catalytic cycle, and density functional theory calculations support the prop...

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Publication status:
Published

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Publisher copy:
10.1021/ja302096r

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Journal:
Journal of the American Chemical Society
Volume:
134
Issue:
17
Pages:
7553-7557
Publication date:
2012-05-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:72c7fd66-16c6-4260-857b-0dbe67becedb
Source identifiers:
325200
Local pid:
pubs:325200

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