Journal article
Allosteric initiation and regulation of catalysis with a molecular knot
- Abstract:
-
Molecular knots occur in DNA, proteins, and other macromolecules. However, the benefits that can potentially arise from tying molecules in knots are, for the most part, unclear. Here, we report on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical reactions by controlling the in situ generation of a carbocation formed through the knot-promoted cleavage of a carbon-halogen bond. The knot architecture is crucial to this function because it restric...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1126/science.aaf3673
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Authors
Funding
+ European Union's Seventh Framework Program
More from this funder
Grant:
FP7-PEOPLE-2013-ITN-607602
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 352
- Issue:
- 6293
- Pages:
- 1555-1559
- Publication date:
- 2016-06-24
- Acceptance date:
- 2016-05-17
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Source identifiers:
-
729602
Item Description
- Keywords:
- Pubs id:
-
pubs:729602
- UUID:
-
uuid:72bd6736-3563-49fb-97ef-4a9b5ab396d0
- Local pid:
- pubs:729602
- Deposit date:
- 2018-01-12
Terms of use
- Copyright holder:
- © 2016, American Association for the Advancement of Science
- Copyright date:
- 2016
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