- Abstract:
-
Molecular knots occur in DNA, proteins, and other macromolecules. However, the benefits that can potentially arise from tying molecules in knots are, for the most part, unclear. Here, we report on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical reactions by controlling the in situ generation of a carbocation formed through the knot-promoted cleavage of a carbon-halogen bond. The knot architecture is crucial to this function because it restric...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1126/science.aaf3673
-
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- Grant:
- FP7-PEOPLE-2013-ITN-607602
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 352
- Issue:
- 6293
- Pages:
- 1555-1559
- Publication date:
- 2016-06-24
- Acceptance date:
- 2016-05-17
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Pubs id:
-
pubs:729602
- URN:
-
uri:72bd6736-3563-49fb-97ef-4a9b5ab396d0
- UUID:
-
uuid:72bd6736-3563-49fb-97ef-4a9b5ab396d0
- Local pid:
- pubs:729602
- Paper number:
- 6293
- Keywords:
- Copyright holder:
- © 2016, American Association for the Advancement of Science
- Copyright date:
- 2016
Journal article
Allosteric initiation and regulation of catalysis with a molecular knot
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+ European Union's Seventh Framework Program
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