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Allosteric initiation and regulation of catalysis with a molecular knot

Abstract:

Molecular knots occur in DNA, proteins, and other macromolecules. However, the benefits that can potentially arise from tying molecules in knots are, for the most part, unclear. Here, we report on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical reactions by controlling the in situ generation of a carbocation formed through the knot-promoted cleavage of a carbon-halogen bond. The knot architecture is crucial to this function because it restric...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aaf3673

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
352
Issue:
6293
Pages:
1555-1559
Publication date:
2016-06-24
Acceptance date:
2016-05-17
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:729602
URN:
uri:72bd6736-3563-49fb-97ef-4a9b5ab396d0
UUID:
uuid:72bd6736-3563-49fb-97ef-4a9b5ab396d0
Local pid:
pubs:729602
Paper number:
6293
Keywords:

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