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Changes in brain Glx in depressed bipolar patients treated with lamotrigine: a proton MRS study

Abstract:
Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers glutamate release. The aim of the current study was to assess the effect of lamotrigine on brain glutamate in depressed bipolar patients and to determine whether baseline glutamate could be used to predict clinical response.

Methods We... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.jad.2018.12.092

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0001-5376-0431
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
ORCID:
0000-0002-8164-7919
Bargiotas, T More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Publisher:
Elsevier Publisher's website
Journal:
Journal of Affective Disorders Journal website
Volume:
246
Pages:
418-421
Publication date:
2018-12-25
Acceptance date:
2018-12-24
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
Pubs id:
pubs:955223
URN:
uri:72b8da95-4899-4f2a-a4d7-61d0fe03d8d4
UUID:
uuid:72b8da95-4899-4f2a-a4d7-61d0fe03d8d4
Local pid:
pubs:955223

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