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Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.

Abstract:

Vascular disrupting agents (VDA) cause acute shutdown of abnormal established tumor vasculature, followed by massive intratumoral hypoxia and necrosis. However, a viable rim of tumor tissue invariably remains from which tumor regrowth rapidly resumes. We have recently shown that an acute systemic mobilization and homing of bone marrow-derived circulating endothelial precursor (CEP) cells could promote tumor regrowth following treatment with either a VDA or certain chemotherapy drugs. The mole...

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Publication status:
Published

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Authors


Woloszynek, J More by this author
Daenen, LG More by this author
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Journal:
Cancer research
Volume:
69
Issue:
19
Pages:
7524-7528
Publication date:
2009-10-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:728a569d-27aa-4a9c-92d2-c99b17b8653e
Source identifiers:
125090
Local pid:
pubs:125090

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