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The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.

Abstract:

BACKGROUND: Doxycycline and micronized purified flavonoid fraction (MPFF) modulate vein wall remodeling that may be associated with hypoxia in varicose veins (VVs), vein graft stenosis, and deep venous thrombosis. We recently reported that in vitro exposure of non-VV (NVVs) and VVs to hypoxic conditions activates the hypoxia-inducible factor (HIF) pathway. This study investigated the in vitro effects of doxycycline and MPFF on the HIF pathway in hypoxic NVVs and VVs. METHODS: Six NVVs and si...

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Publisher copy:
10.1016/j.jvs.2012.02.067

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Paleolog, EM More by this author
Davies, AH More by this author
Journal:
Journal of vascular surgery
Volume:
56
Issue:
4
Pages:
1069-1077
Publication date:
2012-10-05
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
URN:
uuid:727ca5e3-0442-488c-8d97-df6e1cb12ac6
Source identifiers:
377533
Local pid:
pubs:377533

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