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Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.

Abstract:

The processing of stalled replication forks and the repair of collapsed replication forks are essential functions in all organisms. In fission yeast DNA junctions at stalled replication forks appear to be processed by either the Rqh1 DNA helicase or Mus81-Eme1 endonuclease. Accordingly, we show that the hypersensitivity to agents that cause replication fork stalling of mus81, eme1, and rqh1 mutants is suppressed by a Holliday junction resolvase (RusA), as is the synthetic lethality of a mus81...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m202120200

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
277
Issue:
36
Pages:
32753-32759
Publication date:
2002-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:726a1916-b1ad-4a70-83aa-e3e5ade355a0
Source identifiers:
100175
Local pid:
pubs:100175

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