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Coralyne has a preference for intercalation between TA.T triples in intramolecular DNA triple helices.

Abstract:

Intercalating ligands may improve both the stability and sequence specificity of triple helices. Numerous intercalating drugs have been described, including coralyne, which preferentially binds triple helices, though its sequence specificity has been reported to be low [Lee,J.S., Latimer,L.J.P. and Hampel,K.J. (1993) Biochemistry , 32, 5591-5597]. In order to analyse the sequence preferences of coralyne we have used a combination of DNase I footprinting, UV melting, UV-visible spectrophotomet...

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Publication status:
Published

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Publisher copy:
10.1093/nar/25.10.1890

Authors


Moraru-Allen, AA More by this author
Cassidy, S More by this author
Asensio Alvarez, JL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Nucleic acids research
Volume:
25
Issue:
10
Pages:
1890-1896
Publication date:
1997-05-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:72626c8c-ec57-4ea5-a450-cb2e9c1fb1a6
Source identifiers:
400077
Local pid:
pubs:400077

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