Journal article
A high-affinity calmodulin-binding site in the CyaA toxin translocation domain is essential for invasion of eukaryotic cells
- Abstract:
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The molecular mechanisms and forces involved in the translocation of bacterial toxins into host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from Bordetella pertussis displays a unique intoxication pathway in which its catalytic domain is directly translocated across target cell membranes. The CyaA translocation region contains a segment, P454 (residues 454-484), which exhibits membrane-active properties related to antimicrobial peptides....
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1002/advs.202003630
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Funding
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Advanced Science More from this journal
- Volume:
- 8
- Issue:
- 9
- Article number:
- 2003630
- Place of publication:
- Germany
- Publication date:
- 2021-03-08
- DOI:
- EISSN:
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2198-3844
- Pmid:
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33977052
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1488940
- Local pid:
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pubs:1488940
- Deposit date:
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2024-03-15
Terms of use
- Copyright holder:
- Voegele et al
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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